Eric von Hippel , Susumu Ogawa and Jeroen

Unusual diagnosis of Von Hippel Lindau syndrome on PET/CT - Case report and brief review of literature

  We report an unusual case of a young male with cerebellar hemangioblastoma treated previously for medullary carcinoma of thyroid, whose PET/CT scans revealed a constellation of findings that suggested the rare Von Hippel Lindau syndrome. The diagnosis was clinched by confirming the findings on whole body contrast enhanced computed tomography (CECT) and contrast enha...

Zebrafish mutants in the von Hippel-Lindau (VHL) tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia

Zebrafish mutants in the von Hippel-Lindau (VHL) tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia Ellen van Rooijen, Emile E. Voest, Ive Logister, Jeroen Korving, Thorsten Schwerte, Stefan Schulte-Merker, Rachel H. Giles and Fredericus J. van Eeden 1) Dept. Medical Oncology, University Medical Center, Utrecht, The Netherlands 2) Hubrecht Institute...

Recurrent hemorrhage in hemangioblastoma involving the posterior fossa: Case report

BACKGROUND Hemangioblastomas (HGBs) are the most common primary intra-axial posterior fossa tumor in adults. Although spontaneous hemorrhage of these tumors is exceedingly rare, despite their vascular nature, we describe a case of recurrent hemorrhage with associated tonsillar herniation, and demonstrate that a surgical approach can provide a suitable outcome. CASE DESCRIPTION A 54-year-old f...

Customers as Innovators: A New Way to Create Value

Competitive Paper

In the late 1970s, a new research impetus occurred in the new product development literature with the publications of Eric Von Hippel's two seminal investigations (1976; 1977), where he advocated the involvement of users in the idea generation stage of the new product development process. Von Hippel‟s conceptualisation of a customer active paradigm (1978) gave focus to a new generation of resea...